SIRF: A Single-cell Assay for in situ Protein Interaction with Nascent DNA Replication Forks
The duplication of DNA is a basic course of that’s required for the switch of the genetic data from mum or dad to daughter cells. Aberrant DNA replication course ofes are related with various illness phenotypes, together with developmental defects, ageing issues, blood issues comparable to Fanconi Anemia, elevated irritation and most cancers. Therefore, the event of instruments to check proteins related with error-free DNA replication course ofes is of paramount significance. So far, strategies to check proteins related with nascent replication forks relied on typical immunofluorescence and immunoprecipitation assays of 5′-ethylene-2′-deoxyuridine (EdU) labeled DNA (iPOND).
While significantly informative and vital, these strategies lack specificities for nascent fork interactions (e.g., IF) or assay a median change of tens of millions of cells with out single-cell decision (e.g., iPOND). The assay system described right here combines proximity ligation assay (PLA) with EdU coupled click-iT chemistry, which we termed “in situ protein interplay with nascent DNA replication forks (SIRF)”. This technique allows delicate and quantitative evaluation of protein interactions with nascent DNA replication forks with single-cell decision, and may additional be paired with typical immunofluorescence marker evaluation for added multi-parameter evaluation. New insights have been offered into each the atmospheric chemistry of isoprene and the picturechemistry of TiO2 nanoparticles.
Titania (TiO2) nanoparticles are lively photocatalysts, and isoprene (C5H8) is a biogenic risky natural compound that contributes crucially to international particulate matter era. Herein, the direct photooxidation of isoprene by titanium oxide cluster anions with dimensions as much as a nanosize by each ultraviolet (UV) and visual (Vis) gentle excitations has been efficiently recognized via mass spectrometric experiments mixed with quantum chemistry calculations. The potential position of “dry” titania in atmospheric isoprene oxidation has been revealed, and a transparent image of the photooxidation mechanism on titanium oxide nanoparticles has been offered explicitly on the molecular stage.
The adsorption of isoprene on the atomic oxygen radicals (O•-) of titanium oxide clusters results in the formation of the essential interfacial state (IS) inside the band hole of titanium oxides. This IS is demonstrated to be the numerous issue in delivering the electron from the π orbital of C5H8 to the Ti3d orbital in the photooxidation course of and creating photoactivity in the Vis area. It is revealed that after the photogeneration of the O•- radicals by UV excitation on the TiO2 particle floor, the next reactions will be induced by Vis excitation via the IS. This multicolor technique in each the UV and Vis areas can improve the effectivity of photo voltaic vitality harvesting and enhance the product yield of the photocatalysis on TiO2 nanoparticles.
Computational Analysis Reveals a Critical Point Mutation in the N-Terminal Region of the Signaling Lymphocytic Activation Molecule Responsible for the Cross-Species Infection with Canine Distemper Virus
Infection of hosts by morbilliviruses is facilitated by the interplay between viral hemagglutinin (H-protein) and the signaling lymphocytic activation molecule (SLAM). Recently, the purposeful significance of the n-terminal area of human SLAM as a measles virus receptor was demonstrated. However, the purposeful roles of this area in the an infection course of by different morbilliviruses and host vary willpower stay unknown, partly as a result of this area is extremely versatile, which has hampered correct construction willpower of this area by X-ray crystallography.
In this examine, we analyzed the interplay between the H-protein from canine distemper virus (CDV-H) and SLAMs by a computational chemistry method. Molecular dynamics simulations and fragment molecular orbital evaluation demonstrated that the distinctive His28 in the N-terminal area of SLAM from Macaca is a key determinant that allows the formation of a secure interplay with CDV-H, offering a foundation for CDV an infection in Macaca. The computational chemistry method offered ought to allow the willpower of molecular interactions involving areas of proteins which can be tough to foretell from crystal buildings due to their excessive flexibility.
Reaction Mechanisms and Rate Constants of Auto-Catalytic Urethane Formation and Cleavage Reactions
The chemistry of urethanes performs a key position in vital industrial course ofes. Although catalysts are sometimes used, the examine of the reactions with out added catalysts gives the idea for a deeper understanding. For the non-catalytic urethane formation and cleavage reactions, the dominating response mechanism has lengthy been debated. To our information, the response kinetics haven’t been predicted quantitatively thus far. Therefore, we report a brand new computational examine of urethane formation and cleavage reactions. To analyze varied potential response mechanisms and to foretell the response charge constants quantum chemistry and transition state concept have been employed. For validation, experimental knowledge from literature and from personal experiments have been used. Quantitative settlement of experiments and predictions might be demonstrated.
 Cefuroxime Sodium |
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| C023-1G | TOKU-E | 1 g | EUR 121 |
Cefuroxime Sodium |
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| C023-5G | TOKU-E | 5 g | EUR 335 |
) Cefuroxime (sodium) |
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| HY-B1256 | MedChemExpress | 1g | EUR 160 |
 Cefuroxime |
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| GA9610-100MG | Glentham Life Sciences | 100 mg | EUR 70 |
Cefuroxime |
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| GA9610-1G | Glentham Life Sciences | 1 g | EUR 156 |
Cefuroxime |
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| GA9610-250MG | Glentham Life Sciences | 250 mg | EUR 94 |
) Thyroxine (Sodium salt) |
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| 30-AT52 | Fitzgerald | 1 gram | EUR 352 |
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Description: High purity Thyroxine sodium salt |
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) Triiodothyronine (Sodium salt) |
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| 30-AT53 | Fitzgerald | 1 gram | EUR 849 |
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Description: High purity (>99%) Triiodothyronine sodium salt |
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 Nigericin sodium salt |
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| 2096-25 | Biovision | EUR 387 | |
Nigericin sodium salt |
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| 2096-5 | Biovision | EUR 147 | |
 NADP, sodium salt |
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| 2737-100 | Biovision | EUR 153 | |
NADP, sodium salt |
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| 2737-1000 | Biovision | EUR 784 | |
NADP, sodium salt |
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| 2737-500 | Biovision | EUR 457 | |
 Resazurin, sodium salt |
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| 10054 | Biotium | 10MG | EUR 148 |
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Description: Minimum order quantity: 1 unit of 10MG |
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 Novobiocin Sodium Salt |
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| B1526-1G | Biovision | EUR 109 | |
Novobiocin Sodium Salt |
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| B1526-5G | Biovision | EUR 240 | |
 Cefazolin Sodium Salt |
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| B1530-1G | Biovision | EUR 142 | |
Cefazolin Sodium Salt |
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| B1530-5G | Biovision | EUR 359 | |
 Cefoxitin Sodium Salt |
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| B1892-1G | Biovision | EUR 185 | |
Cefoxitin Sodium Salt |
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| B1892-500 | Biovision | EUR 131 | |
Cefoxitin Sodium Salt |
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| B1892-5G | Biovision | EUR 577 | |
 Azlocillin sodium salt |
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| B1893-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 108 |
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Description: Azlocillin is an acylampicillin with a broad spectrum against bacteria. |
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Azlocillin sodium salt |
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| B1893-50 | ApexBio | 50 mg | EUR 128 |
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Description: Azlocillin is an acylampicillin with a broad spectrum against bacteria. |
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Azlocillin sodium salt |
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| B1893-S | ApexBio | Evaluation Sample | EUR 81 |
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Description: Azlocillin is an acylampicillin with a broad spectrum against bacteria. |
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 Sulfamerazine sodium salt |
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| B3430-100000 | ApexBio | 100 g | EUR 137 |
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Description: Sulfamerazine Sodium is a sulfonamide antibacterial. |
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Sulfamerazine sodium salt |
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| B3430-50000 | ApexBio | 50 g | EUR 110 |
|
Description: Sulfamerazine Sodium is a sulfonamide antibacterial. |
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 GSK2190915 sodium salt |
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| B4905-10 | ApexBio | 10 mg | EUR 429 |
GSK2190915 sodium salt |
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| B4905-5 | ApexBio | 5 mg | EUR 277 |
GSK2190915 sodium salt |
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| B4905-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 380 |
GSK2190915 sodium salt |
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| B4905-50 | ApexBio | 50 mg | EUR 1549 |
 Ischemin sodium salt |
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| B4917-10 | ApexBio | 10 mg | EUR 268 |
Ischemin sodium salt |
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| B4917-50 | ApexBio | 50 mg | EUR 973 |
 Proglumide sodium salt |
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| B5121-100 | ApexBio | 100 mg | EUR 139 |
Proglumide sodium salt |
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| B5121-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 150 |
 Entacapone sodium salt |
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| B1090-10 | ApexBio | 10 mg | EUR 139 |
|
Description: Entacapone, a nitrocatechol compound, is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), a Mg2+-dependent enzyme involved in the metabolism of catecholamines and catechol compounds. |
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Entacapone sodium salt |
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| B1090-100 | ApexBio | 100 mg | EUR 321 |
|
Description: Entacapone, a nitrocatechol compound, is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), a Mg2+-dependent enzyme involved in the metabolism of catecholamines and catechol compounds. |
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Entacapone sodium salt |
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| B1090-50 | ApexBio | 50 mg | EUR 231 |
|
Description: Entacapone, a nitrocatechol compound, is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), a Mg2+-dependent enzyme involved in the metabolism of catecholamines and catechol compounds. |
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 Adapalene sodium salt |
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| B1277-100 | ApexBio | 100 mg | EUR 142 |
|
Description: Adapalene sodium salt, a synthetic retinoid, is a Retinoic acid receptor agonist (RAR). |
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Adapalene sodium salt |
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| B1277-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 108 |
|
Description: Adapalene sodium salt, a synthetic retinoid, is a Retinoic acid receptor agonist (RAR). |
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Adapalene sodium salt |
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| B1277-50 | ApexBio | 50 mg | EUR 108 |
|
Description: Adapalene sodium salt, a synthetic retinoid, is a Retinoic acid receptor agonist (RAR). |
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 GSK1349572 sodiuM salt |
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| B5856-10 | ApexBio | 10 mg | EUR 316 |
|
Description: Integrase inhibitors are a new class of antiretroviral drugs blocking the action of HIV integrase, which catalyses several key steps in the life cycle of the virus and is essential for insertion of the viral genome into the host cell DNA. GSK1349572 is a next-generation HIV integrase (IN) inhibitor. |
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GSK1349572 sodiuM salt |
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| B5856-100 | ApexBio | 100 mg | EUR 1210 |
|
Description: Integrase inhibitors are a new class of antiretroviral drugs blocking the action of HIV integrase, which catalyses several key steps in the life cycle of the virus and is essential for insertion of the viral genome into the host cell DNA. GSK1349572 is a next-generation HIV integrase (IN) inhibitor. |
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GSK1349572 sodiuM salt |
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| B5856-5 | ApexBio | 5 mg | EUR 241 |
|
Description: Integrase inhibitors are a new class of antiretroviral drugs blocking the action of HIV integrase, which catalyses several key steps in the life cycle of the virus and is essential for insertion of the viral genome into the host cell DNA. GSK1349572 is a next-generation HIV integrase (IN) inhibitor. |
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GSK1349572 sodiuM salt |
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| B5856-50 | ApexBio | 50 mg | EUR 728 |
|
Description: Integrase inhibitors are a new class of antiretroviral drugs blocking the action of HIV integrase, which catalyses several key steps in the life cycle of the virus and is essential for insertion of the viral genome into the host cell DNA. GSK1349572 is a next-generation HIV integrase (IN) inhibitor. |
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 Resazurin sodium salt |
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| B6098-1000 | ApexBio | 1 g | EUR 84 |
|
Description: The non-fluorescent resazurin has been used as a fluorogenic oxidation-reduction indicator in various cells by flow cytometry, fluorescence microscopy and high-throughput screening. Its red-fluorescent product, resorufin, has absorption/emission maxima ~575/585 nm. |
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Resazurin sodium salt |
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| B6098-5000 | ApexBio | 5 g | EUR 166 |
|
Description: The non-fluorescent resazurin has been used as a fluorogenic oxidation-reduction indicator in various cells by flow cytometry, fluorescence microscopy and high-throughput screening. Its red-fluorescent product, resorufin, has absorption/emission maxima ~575/585 nm. |
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 Dantrolene, sodium salt |
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| B6329-100 | ApexBio | 100 mg | EUR 132 |
Dantrolene, sodium salt |
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| B6329-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 108 |
 Cefotaxime Sodium Salt |
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| abx188641-100g | Abbexa | 100 g | EUR 509 |
|
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 Tianeptine Sodium Salt |
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| abx188914-25g | Abbexa | 25 g | EUR 314 |
|
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Cefotaxime Sodium Salt |
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| 20-abx082178 | Abbexa |
|
|
|
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 PIPES Sodium Salt |
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| 20-abx082438 | Abbexa |
|
|
|
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 Carboxymethylcellulose sodium salt |
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| abx082467-100g | Abbexa | 100 g | EUR 189 |
|
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 Ampicillin Sodium Salt |
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| abx082587-5g | Abbexa | 5 g | EUR 175 |
|
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) Fosmidomycin (sodium salt) |
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| C4898-10 | ApexBio | 10 mg | EUR 415 |
|
Description: Fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXP) [1]. Fosmidomycin is an antibiotic originally isolated from bacteria of the genus Streptomyces. |
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Fosmidomycin (sodium salt) |
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| C4898-25 | ApexBio | 25 mg | EUR 830 |
|
Description: Fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXP) [1]. Fosmidomycin is an antibiotic originally isolated from bacteria of the genus Streptomyces. |
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Fosmidomycin (sodium salt) |
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| C4898-5 | ApexBio | 5 mg | EUR 244 |
|
Description: Fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXP) [1]. Fosmidomycin is an antibiotic originally isolated from bacteria of the genus Streptomyces. |
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) Cefsulodin (sodium salt) |
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| C5593-1000 | ApexBio | 1 g | EUR 224 |
|
Description: Cefsulodin, formerly named as SCE-129, is a cephalosporin with a spectrum of antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and most other gram-positive cocci [1]. |
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Cefsulodin (sodium salt) |
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| C5593-250 | ApexBio | 250 mg | EUR 123 |
|
Description: Cefsulodin, formerly named as SCE-129, is a cephalosporin with a spectrum of antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and most other gram-positive cocci [1]. |
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Cefsulodin (sodium salt) |
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| C5593-500 | ApexBio | 500 mg | EUR 180 |
|
Description: Cefsulodin, formerly named as SCE-129, is a cephalosporin with a spectrum of antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and most other gram-positive cocci [1]. |
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) Furegrelate (sodium salt) |
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| C5692-10 | ApexBio | 10 mg | EUR 170 |
|
Description: Furegrelate (sodium salt) is a potent inhibitor of thromboxane synthase [1][2].Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) is a cytochrome P450 enzyme that catalyzes the conversion of prostaglandin H2 to thromboxane A2. |
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Furegrelate (sodium salt) |
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| C5692-5 | ApexBio | 5 mg | EUR 112 |
|
Description: Furegrelate (sodium salt) is a potent inhibitor of thromboxane synthase [1][2].Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) is a cytochrome P450 enzyme that catalyzes the conversion of prostaglandin H2 to thromboxane A2. |
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Furegrelate (sodium salt) |
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| C5692-50 | ApexBio | 50 mg | EUR 551 |
|
Description: Furegrelate (sodium salt) is a potent inhibitor of thromboxane synthase [1][2].Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) is a cytochrome P450 enzyme that catalyzes the conversion of prostaglandin H2 to thromboxane A2. |
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 Hepes, Sodium Salt |
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| CH039 | ABM | 25 g | EUR 118 |
Hepes, Sodium Salt |
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| CH040 | ABM | 100 g | EUR 169 |
Hepes, Sodium Salt |
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| CH041 | ABM | 500 g | EUR 374 |
) Lorglumide (sodium salt) |
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| C4809-25 | ApexBio | 25 mg | EUR 145 |
|
Description: Lorglumide (sodium salt) is the first nonpeptidic, selective and potent inhibitor of the CCK-A receptor [1][2][3][4] . |
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Lorglumide (sodium salt) |
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| C4809-50 | ApexBio | 50 mg | EUR 171 |
|
Description: Lorglumide (sodium salt) is the first nonpeptidic, selective and potent inhibitor of the CCK-A receptor [1][2][3][4] . |
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) Cefoxitin (sodium salt) |
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| C4849-1000 | ApexBio | 1 g | EUR 241 |
|
Description: Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2]. |
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Cefoxitin (sodium salt) |
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| C4849-250 | ApexBio | 250 mg | EUR 113 |
|
Description: Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2]. |
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Cefoxitin (sodium salt) |
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| C4849-500 | ApexBio | 500 mg | EUR 164 |
|
Description: Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2]. |
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 Cefamandole sodium salt |
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| C079-100MG | TOKU-E | 100 mg | EUR 148 |
Cefamandole sodium salt |
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| C079-500MG | TOKU-E | 500 mg | EUR 474 |
) Moxalactam (sodium salt) |
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| C4121-1000 | ApexBio | 1 g | EUR 225 |
|
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis. |
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Moxalactam (sodium salt) |
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| C4121-250 | ApexBio | 250 mg | EUR 112 |
|
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis. |
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Moxalactam (sodium salt) |
|||
| C4121-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 113 |
|
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis. |
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Moxalactam (sodium salt) |
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| C4121-500 | ApexBio | 500 mg | EUR 168 |
|
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis. |
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) Cefazolin (sodium salt) |
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| C4183-1000 | ApexBio | 1 g | EUR 168 |
|
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1]. |
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Cefazolin (sodium salt) |
|||
| C4183-250 | ApexBio | 250 mg | EUR 105 |
|
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1]. |
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Cefazolin (sodium salt) |
|||
| C4183-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 113 |
|
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1]. |
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Cefazolin (sodium salt) |
|||
| C4183-500 | ApexBio | 500 mg | EUR 138 |
|
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1]. |
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) Tazobactam (sodium salt) |
|||
| C4245-1000 | ApexBio | 1 g | EUR 226 |
|
Description: Tazobactam is a ?-lactamase inhibitor [1]. Tazobactam shows intrinsic activity against Acinetobacter strains. The ?-Lactamases are responsible for resistance to penicillins, extended-spectrum cephalosporins, monobactams, and carbapenems. |
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Tazobactam (sodium salt) |
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| C4245-250 | ApexBio | 250 mg | EUR 116 |
|
Description: Tazobactam is a ?-lactamase inhibitor [1]. Tazobactam shows intrinsic activity against Acinetobacter strains. The ?-Lactamases are responsible for resistance to penicillins, extended-spectrum cephalosporins, monobactams, and carbapenems. |
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Tazobactam (sodium salt) |
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| C4245-500 | ApexBio | 500 mg | EUR 168 |
|
Description: Tazobactam is a ?-lactamase inhibitor [1]. Tazobactam shows intrinsic activity against Acinetobacter strains. The ?-Lactamases are responsible for resistance to penicillins, extended-spectrum cephalosporins, monobactams, and carbapenems. |
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) Simvastatin (sodium salt) |
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| C4426-100 | ApexBio | 100 mg | EUR 392 |
|
Description: Ki: 0.12 nMSimvastatin is a HMG-CoA reductase inhibitor. HMG-CoA reductase has been found to be the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the ?statin? class of cholesterol-lowering drugs. |
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Simvastatin (sodium salt) |
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| C4426-25 | ApexBio | 25 mg | EUR 196 |
|
Description: Ki: 0.12 nMSimvastatin is a HMG-CoA reductase inhibitor. HMG-CoA reductase has been found to be the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the ?statin? class of cholesterol-lowering drugs. |
|||
) Moniliformin (sodium salt) |
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| C4459-1 | ApexBio | 1 mg | EUR 321 |
|
Description: Moniliformin induces mitotic arrest at the metaphase stage.Mitosis is a part of the cell cycle when replicated chromosomes are separated into two new nuclei. |
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) Cefotaxime (sodium salt) |
|||
| C4588-1000 | ApexBio | 1 g | EUR 126 |
|
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic. |
|||
Cefotaxime (sodium salt) |
|||
| C4588-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 113 |
|
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic. |
|||
Cefotaxime (sodium salt) |
|||
| C4588-500 | ApexBio | 500 mg | EUR 108 |
|
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic. |
|||
Cefotaxime (sodium salt) |
|||
| C4588-5000 | ApexBio | 5 g | EUR 151 |
|
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic. |
|||
) Methicillin (sodium salt) |
|||
| C3238-100 | ApexBio | 100 mg | EUR 145 |
|
Description: Methicillin is a semisynthetic penicillin antibiotic.In vitro: Similar to other ?-lactam antibiotics, meticillin acts via inhibiting the synthesis of bacterial cell walls. |
|||
Methicillin (sodium salt) |
|||
| C3238-250 | ApexBio | 250 mg | EUR 226 |
|
Description: Methicillin is a semisynthetic penicillin antibiotic.In vitro: Similar to other ?-lactam antibiotics, meticillin acts via inhibiting the synthesis of bacterial cell walls. |
|||
Methicillin (sodium salt) |
|||
| C3238-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 113 |
|
Description: Methicillin is a semisynthetic penicillin antibiotic.In vitro: Similar to other ?-lactam antibiotics, meticillin acts via inhibiting the synthesis of bacterial cell walls. |
|||
Methicillin (sodium salt) |
|||
| C3238-50 | ApexBio | 50 mg | EUR 108 |
|
Description: Methicillin is a semisynthetic penicillin antibiotic.In vitro: Similar to other ?-lactam antibiotics, meticillin acts via inhibiting the synthesis of bacterial cell walls. |
|||
) Ertapenem (sodium salt) |
|||
| C3451-10 | ApexBio | 10 mg | EUR 241 |
|
Description: Ertapenem, the first group of carbapenems, is a 1-?-methyl carbapenem with potent in vitro activity against a broad spectrum of bacterial pathogens including Gram-positive and Gram-negative aerobic and anaerobic pathogens [1]. |
|||
Ertapenem (sodium salt) |
|||
| C3451-25 | ApexBio | 25 mg | EUR 448 |
|
Description: Ertapenem, the first group of carbapenems, is a 1-?-methyl carbapenem with potent in vitro activity against a broad spectrum of bacterial pathogens including Gram-positive and Gram-negative aerobic and anaerobic pathogens [1]. |
|||
Ertapenem (sodium salt) |
|||
| C3451-5 | ApexBio | 5 mg | EUR 163 |
|
Description: Ertapenem, the first group of carbapenems, is a 1-?-methyl carbapenem with potent in vitro activity against a broad spectrum of bacterial pathogens including Gram-positive and Gram-negative aerobic and anaerobic pathogens [1]. |
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The calculations affirm earlier assumptions that urethane formation reactions proceed by way of mechanisms the place alcohol molecules act as auto-catalysts. Our outcomes present that it’s important to think about a number of transition states similar to completely different response orders to allow settlement with experimental observations. Urethane cleavage appears to be catalyzed by an isourethane, resulting in an noticed 2nd-order dependence of the response charge on the urethane focus. The outcomes of our examine assist a deeper understanding of the reactions in addition to a greater description of response kinetics and can subsequently assist in catalyst improvement and course of optimization.